Nothing is known about his parentage and his early life besides his birth in Dhaka, where he came under the influence of Anil Roy, the nationalist intellectual who founded the Shree Samgha of Dhaka.
A contemporary of Dr. Naren Roy in the Calcutta Medical College, Dr. Basu (1902 -1981) was also in the nationalist group of the renowned medical practitioner of Calcutta, Dr. Amiya Kumar Basu, and was known to Bhupendranath Datta. But, unlike Dr. Naren Roy, Bhupal Basu’s direct involvement in bomb manufacturing is not known but he was very close to him.
On 25 August 1930, at Dalhousie Square, Dineshchancra Majumdar and Anujacharan Sen threw bombs on Charles Tegart, notorious police commissioner of Calcutta. Anujacharan Sen died in the explosion, while Dineshchandra was arrested a little away. Dr. Basu, like Dr. Roy, was nowhere near the spot; but his name surfaced in course of the investigation of the Dalhousie Square Bomb Case and the Calcutta Bomb Case and was interned in the Alipore Central Jail as under trial.
Finally, the special court sentenced Dr. Basu along with Dr. Narayan Roy and sent to the Cellular Jail. Released in 1938, Dr. Basu, after the Haripura fiasco left the Congress and joined the Forward Bloc founded by Subhas Chandra Bose. Away from politics, he devoted himself to social work in his later life, stretching out his helping hands to the riot victims of Calcutta.